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For patients whose disease has failed to respond to a macrolide-containing regimen and who have progressive, symptomatic disease, an alternative drug regimen or surgery will be necessary.

The second is an active drug efflux mechanism, which is determined by the presence of the membrane-bound efflux protein, encoded by the mef(A) gene.

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In a subset of our hypersomnia patients, there is a naturally-occurring substance that causes the GABA receptor to be hyperactive.

The risk appears to be greater when ethambutol is given on a daily basis versus intermittent (three times weekly) administration ().

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Cases of rhabdomyolysis have been reported in patients taking BIAXIN concomitantly with these statins.

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Azithromycin and clarithromycin also are active against some unexpected pathogens (e.

This treatment does carry potential risks (especially for patients without or subclinical hypothroidism), which include cardiac arrhythmia.

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In community-acquired pneumonia studies conducted in adults comparing Clarithromycin to erythromycin base or erythromycin stearate, there were fewer adverse events involving the digestive system in Clarithromycin-treated patients compared to erythromycin-treated patients (13% vs.

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Assess for history of hypersensitivity to drug, macrolides, β-lactam antibiotics (PCNs, cephalosporins), or other allergens.

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Adult and adolescent patients with CF should have periodic, at least yearly, screening cultures for NTM.

Since the microbiological activities of clarithromycin and 14-OH clarithromycin are different for different bacteria, the intended therapeutic effect could be impaired during concomitant administration of clarithromycin and enzyme inducers.

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Although MAC is not a frequent cause of pulmonary parenchymal disease, it is commonly isolated from the respiratory tract in HIV-infected patients.

Similar results were seen for 14-hydroxy-clarithromycin, the mean C max was 45% greater, the mean C min was 57% greater, and the mean AUC 0-8 was 45% greater.

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As important as identifying predisposing factors for NTM disease is identifying the source(s) of infection both for newly infected and for reinfected patients.

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Serum and milk samples were obtained after 3 days of treatment, at steady state, from one published study of 12 lactating women who were taking BIAXIN 250 mg orally twice daily.

Cyclosporine: There have been spontaneous or published reports of CYP3A based interactions of clarithromycin with cyclosporine.

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Because of high intracellular concentrations, tissue concentrations are higher than serum concentrations.

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Fewer than 3% of adult patients without mycobacterial infections and fewer than 2% of pediatric patients without mycobacterial infections discontinued therapy because of drug-related side effects.

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Liviu L, Yair L, Yehuda S "Pancreatitis induced by clarithromycin.

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Eleven of the patients developed strains of MAC which were resistant to clarithromycin.

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BIAXIN Filmtab tablets and BIAXIN Granules for oral suspension are indicated for the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.

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In the non-parametric self controlled case series analysis we estimated two incidence rate ratio functions, using myocardial infarction as an example to illustrate the incidence rate ratio over time; a function that represents an incidence rate ratio during current use of clarithromycin and an incidence rate ratio function in the washout period up to three years after treatment ended.

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In addition to the requirement of removing the patient from the inciting exposure of the MAC antigen source (contaminated hot tub), the use of antimycobacterial therapy, corticosteroids, or a combination of both or neither is debated.

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Current approach to early, disseminated, and late disease.

We sought to systematically assess the effects of clarithromycin on objective vigilance and subjective sleepiness.

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